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2008•Chinese Heart JournalRequires access

Prevalence and relative factors of clopidogrel resistance in patients undergoing coronary stenting

Hongman Huang

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Abstract

AIM To assess the incidence of clopidogrel resistance in patients undergoing coronary stenting and to exolore the relative factors.METHODS Platelet reactivity was measured by 5 μmol/L ADP-induced aggregation(%) in patients undergoing coronary stenting to determine the clopidogrel resistance.The subjects with resistance and without resistance were assigned to different groups and correlation factors were analyzed and compared between the 2 groups.RESULTS The incidence of clopidogrel resistance was 24.3%.The HOMA-IR,total cholesterol and coronary artery pathological degree were significantly different between the two groups(P0.01).CONCLUSION The incidence of clopidogrel resistance is 24.3% and insulin resistance,total cholesterol and coronary artery pathological degree are some of the relative factors of clopidogrel resistance.

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AIM To assess the incidence of clopidogrel resistance in patients undergoing coronary stenting and to exolore the relative factors.METHODS Platelet reactivity was measured by 5 μmol/L ADP-induced aggregation(%) in patients undergoing coronary stenting to determine the clopidogrel resistance.The subjects with resistance and without resistance were assigned to different groups and correlation factors were analyzed and compared between the 2 groups.RESULTS The incidence of clopidogrel resistance was 24.3%.The HOMA-IR,total cholesterol and coronary artery pathological degree were significantly different between the two groups(P0.01).CONCLUSION The incidence of clopidogrel resistance is 24.3% and insulin resistance,total cholesterol and coronary artery pathological degree are some of the relative factors of clopidogrel resistance.

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Available abstract

AIM To assess the incidence of clopidogrel resistance in patients undergoing coronary stenting and to exolore the relative factors.METHODS Platelet reactivity was measured by 5 μmol/L ADP-induced aggregation(%) in patients undergoing coronary stenting to determine the clopidogrel resistance.The subjects with resistance and without resistance were assigned to different groups and correlation factors were analyzed and compared between the 2 groups.RESULTS The incidence of clopidogrel resistance was 24.3%.The HOMA-IR,total cholesterol and coronary artery pathological degree were significantly different between the two groups(P0.01).CONCLUSION The incidence of clopidogrel resistance is 24.3% and insulin resistance,total cholesterol and coronary artery pathological degree are some of the relative factors of clopidogrel resistance.

Key concepts: Clopidogrel, Medicine, Incidence (geometry), Internal medicine, Cardiology, Insulin resistance, Coronary stenting, Diabetes mellitus

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Prevalence and relative factors of clopidogrel resistance in patients undergoing coronary stenting — Research Paper | ScholarLens