Prevalence and risk factors of clopidogrel resistance after percutaneous coronary intervention in patients over 60 years of age

AIM: To assess the incidence and risk factors of clopidogrel resistance after percutaneous coronary intervention(PCI) with drug-eluting stent in patients 60 years of age.METHODS: The clinical data of 208 patients were collected,among whom 55 patients whose PAR 50% after PCI were assigned to the clopidogrel resistance group and the other 153 patients were assigned to the without resistance group.Correlation factors were analyzed and compared between groups.RESULTS: The incidence of clopidogrel resistance was 26.4% in elderly patients.The level of PAR was(57±6)% vs.(35±9)%(P0.01) between the two groups after PCI.Multivariate logistic regression models found that the risk factor was diabetes mellitus(P=0.037,OR 2.053,95% CI 1.045-4.034).CONCLUSION: The incidence of clopidogrel resistance is 26.4% after PCI with drug-eluting stent in patients 60 years of age,and diabetes mellitus is the risk factor for clopidogrel resistance.