Effect of polygala tenuifolia willd YZ-50 on expression of the Bax、Bcl-2 of chronic stress depression rats

Objective: To investigate the effect of polygala tenuifolia willd YZ-50 on expression of the Bax, Bcl-2 of chronic stress depression rats. Methods: Expression of the Bax, Bcl-2 in the chronic stress depression rats' hippocampus was detected by immunohistochemistry methods with the healthy male Ⅱ grade wistar rats of chronic stress depression rats and the change rule of the Bax, Bcl-2 was discussed from molecular level. Experiment was allocated randomly to five groups: normal control group, model group, desipramine group(20 mg·kg -1)and polygala tenuifolia willd YZ-50 low(2.8 g·kg -1 dried medicinal herb)and high(5.6 g·kg -1 dried medicinal herb)dosage groups. Results: When the chronic stress depression rats model was built successfully, results demon-strated that the expression of the Bax was increased obviously and the Bcl-2 expressed lowly in the model group; Compared with model group, the Bcl-2 showed up-regulation in each dosage of YZ-50, while the Bax decreased significantly(P 0.05). Conclusion: YZ- 50 increased the expression of Bcl-2, inhibited the expression of Bax, controlled the proportion of Bcl-2/Bax to reduce the apoptosis of the neurons and decreased the outside impaired effect towards neurons which improved the depressive state.