Determination of entrapment efficiency ofcurcumin solid lipid nanoparticles byultraviolet spectrophotometry

To establish a methods for determination of the content of curcumin solid lipid nanoparticles. The con-tent of curcumin in curcumin solid lipid nanoparticles was determined by UV spectrophotometry, then the entrapmentefficiency was calculated on the base. The curcumin solid lipid nanoparticles presented as small round or oval undertransmission electron microscope(TEM)with the average diameter of about(130.7 ±2.4) nm. The curcumin had themaximum absorption at wavelength of 432 nm, and there was the good linear relationship range from 1.05 ~ 7.35 ug /m L. The regression equation was as follows: A = 0.1320 C + 0.0310, r = 0.9993(n = 7). The average recovery ratewas 99.39%, RSD= 0.49%. The entrapment efficiency of curcumin solid lipid nanoparticles was 90.90%, RSD =0.82%. The method was simple, rapid and accurate, which can be used for the entrapment efficiency of solid lipidnanoparticles containing curcumin.