Analysis of antimicrobial resistance in 38 strains of Streptococcus pneumoniae isolated from patients with respiratory tract infections

Objective To investigate the antimicrobial resistance of Streptococcus pneumoniae,and to provide guidance for clinical medication.Methods To collect sputum of the patients with respiratory tract infection between January 2009 and June 2010 for cultivating in order to get strains and then to detect the MIC of penicillin and other 15 antibiotics by micro-dilution method.Results Among the 38 strains of Streptococcus pneumoniae,22 strains(57.9%) were sensitive to penicillin,12 strains(31.6%) were resistant,and 4 strains(10.5%) were intermediate.Among the antibiotics,clarithromycin had the highest resistance(78.9%),while vancomycin and meropenem the lowest(0%).Besides,the antimicrobial resistant rate of strains insensitive to penicillin was higher than that of strains sensitive to penicillin.Conclusion The antimicrobial resistance rate of Streptococcus pneumoniae to multidrugs in our hospital is high,suggesting that the clinical doctors should make reasonable choice of antibiotics.