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2013•Chemistry & BioengineeringRequires access

Synthesis and Bioactivity of N-(Substituted)benzyl-N′-benzoyloxy-ethyl Piperazine Derivatives

Han Sheng-hua

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Abstract

Fifteen new N-(substituted)benzyl-N′-benzoyloxy-ethyl piperazine derivatives were synthesized,and their structures were confirmed by IR,1HNMR,elemental analysis and MS.Their inhibitory activities against vascular smooth muscle cells proliferation induced by FBS were evaluated.All the object compounds showed inhibitory activity to a certain extent on vascular smooth muscle cells proliferation,especially compounds Ⅳc,Ⅳd and Ⅳh.

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What this paper is about

Fifteen new N-(substituted)benzyl-N′-benzoyloxy-ethyl piperazine derivatives were synthesized,and their structures were confirmed by IR,1HNMR,elemental analysis and MS.Their inhibitory activities against vascular smooth muscle cells proliferation induced by FBS were evaluated.All the object compounds showed inhibitory activity to a certain extent on vascular smooth muscle cells proliferation,especially compounds Ⅳc,Ⅳd and Ⅳh.

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Available abstract

Fifteen new N-(substituted)benzyl-N′-benzoyloxy-ethyl piperazine derivatives were synthesized,and their structures were confirmed by IR,1HNMR,elemental analysis and MS.Their inhibitory activities against vascular smooth muscle cells proliferation induced by FBS were evaluated.All the object compounds showed inhibitory activity to a certain extent on vascular smooth muscle cells proliferation,especially compounds Ⅳc,Ⅳd and Ⅳh.

Key concepts: Piperazine, Chemistry, Vascular smooth muscle, Inhibitory postsynaptic potential, Elemental analysis, Stereochemistry, Smooth muscle, Medicinal chemistry

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Synthesis and Bioactivity of N-(Substituted)benzyl-N′-benzoyloxy-ethyl Piperazine Derivatives — Research Paper | ScholarLens