Synthesis and activity study of N-(substituted)benzoyl-N′-substituted pyrimidinyl thiourea derivatives

Aim To synthesize a new series of N-(substituted)benzoyl-N′-substituted pyrimidinyl thiourea derivatives and to evaluate their inhibitory activities against vascular smooth muscle cells proliferation.Methods The subject compounds could be obtained by direct amination of(substituted)benzoyl isothiocyanate with 2-amino-5-bromo-4-substituted pyrimidine derivatives.The inhibitory effect of the target compounds on VSMC proliferation was investigated by MTT.Results and conclusion Ten target new compounds were first synthesized and verified by 1H-NMR and MS.Compound 6b,6c,6g and 6j exhibited moderate inhibitory activities against vascular smooth muscle cells proliferation.