Inhibitory effect of antineoplastic polypeptide III(AP III) from APBMV on transplanting hepatoma 22 and influence of AP IIIon thymus gland weight of tumor bearing mice

Aim: To observe the inhibitory effect of antineoplastic polypeptide Ⅲ from APBMV (AP Ⅲ)on mouse hepatoma 22 (H 22 )and influence of AP Ⅲ on thymus gland weight of tumor bearing mice . Methods: Sixty five mice were inoculated by H 22 cells and 24 h later were divided into 5 groups:10 for 5 Fu group (20 mg/kg), 10 for APBMV group (0.04 mg/kg),10 for AP Ⅲ group Ⅰ(0.04 mg/kg), 10 for AP Ⅲ group Ⅱ(0.03 mg/kg) and 25 for non normal control group(saline). The mice were administered by intraperitoneal injection once a day for 10 days and then killed. The weight changes of tumor and thymus gland were observed accurately and statistically. Results: Growth of H 22 was inhibited markedly by AP Ⅲ at two dosages used in this experiment and APBMV, compared with non normal control group, the differences were significant ( P 0.01 or P 0.001), and indexes of thymus gland were lower in 5 Fu group and higher or similar in two AP Ⅲ and APBMV groups. Conclusion: Growth of H 22 was efficiently inhibited by AP Ⅲ .The thymus gland weight of H 22 bearing mice was increased by high dosage of AP Ⅲ.