Drug resistance of Acinetobacter baumannii between 2003 and 2010

OBJECTIVE To investigate the distribution and drug resistance of Acinetobacter baumannii causing nosocomial infections so as to provide scientific basis for the prevention and control of nosocomial infections.METHODS The specimen sources and the clinical distribution of the A.baumannii isolated from 2003 to 2010 were retrospectively analyzed,the drug resistance was observed by Kirby-Bauer method.RESULTS The isolation rate of A.baumannii presented as an upward tendency,the sputum was the major specimens source,accounting for 75.8%,which mainly distributed in the ICU(19.3%),respiratory department(17.0%),cerebral surgery department(13.8%) and hepatology department(11.3%),A.baumannii was highly resistant to the tested antibiotics,the drug resistance rates to carbapenems such as imipenem and meropenem were increased significantly,in addition,the drug resistance rates to amikacin and tobramycin were elevated.CONCLUSION Both the isolation rate and the drug resistance rate of A.baumannii keep an upward tendency from 2003 to 2010,and the multidrug-resistant strains have been increased.In addition to strengthening the clinical monitoring of A.baumannii,it is necessary to reasonably use antibiotics and intensify the medical staff's awareness of sterilization.