Synthesis of 4-hydroxy-3-methoxyphenethylamine hydrochloride

With raw materials of vanillin and nitromethane, 4-Hydroxy-3-methoxyphenethylamine hydrochloride was synthesized via condensation,reduction and hydrochlorination.The structure of the product was confirmed by IR and ~1HNMR.The influence of the reaction temperature,catalyst proportion and reagent mole ratio to the yield of the condensation was studied,and the preparation of reducing agent,reaction temperature and time make the effects on the yield of the reduction was studied also.The yield of the reduction was 66.8%.