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2010•The Practical Journal of CancerRequires access

The Expression of MMP-2 and EGFR in the Tissues from Gastric Carcinoma

Shen Gao

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Abstract

Objective To evaluate the expression of EGFR and matrix metalloproteinase-2(MMP-2) in the tissues from gastric cancer and its relationship with the biological characteristics of gastric cancer.Methods The expression of EGFR and MMP-2 was detected by immunohistochemistry in the tissues from 64 patients with gastric cancer.Results The positive expression of EGFR and MMP-2 was 31.25%(20/64) and 68.75%(44/64);EGFR over-expression was related to the clinical stage,lymph node metastasis,TNM stage and the degree of differentiation(P0.05);MMP-2 over-expression was related to the clinical stage,lymph node metastasis and TNM stage(P0.05),but was not related to the degree of differentiation(P0.05);The expression of EGFR and MMP-2 was positively correlated(P0.05).Conclusion The expressions of EGFR and MMP-2 was correlated in the tissues from gastric cancer.

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What this paper is about

Objective To evaluate the expression of EGFR and matrix metalloproteinase-2(MMP-2) in the tissues from gastric cancer and its relationship with the biological characteristics of gastric cancer.Methods The expression of EGFR and MMP-2 was detected by immunohistochemistry in the tissues from 64 patients with gastric cancer.Results The positive expression of EGFR and MMP-2 was 31.25%(20/64) and 68.75%(44/64);EGFR over-expression was related to the clinical stage,lymph node metastasis,TNM stage and the degree of differentiation(P0.05);MMP-2 over-expression was related to the clinical stage,lymph node metastasis and TNM stage(P0.05),but was not related to the degree of differentiation(P0.05);The expression of EGFR and MMP-2 was positively correlated(P0.05).Conclusion The expressions of EGFR and MMP-2 was correlated in the tissues from gastric cancer.

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Available abstract

Objective To evaluate the expression of EGFR and matrix metalloproteinase-2(MMP-2) in the tissues from gastric cancer and its relationship with the biological characteristics of gastric cancer.Methods The expression of EGFR and MMP-2 was detected by immunohistochemistry in the tissues from 64 patients with gastric cancer.Results The positive expression of EGFR and MMP-2 was 31.25%(20/64) and 68.75%(44/64);EGFR over-expression was related to the clinical stage,lymph node metastasis,TNM stage and the degree of differentiation(P0.05);MMP-2 over-expression was related to the clinical stage,lymph node metastasis and TNM stage(P0.05),but was not related to the degree of differentiation(P0.05);The expression of EGFR and MMP-2 was positively correlated(P0.05).Conclusion The expressions of EGFR and MMP-2 was correlated in the tissues from gastric cancer.

Key concepts: Matrix metalloproteinase, Immunohistochemistry, Stage (stratigraphy), Lymph node metastasis, Gastric carcinoma, Cancer, Medicine, Metastasis

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