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2005•Journal of Harbin University of CommerceRequires access

Treatment effect of Yinzhiku on rats with hepatic fibrosis

JI Yu-bin

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Abstract

To investigate the effects of compound Yinzhiku on hepatic fibrosis in rats. The expression of mRNA and proteins of TGF-β1, MMP-13 and TIMP-1 were detected by RT-PCR and immunohistochemistry after liver fibrosis. The levels of mRNA and protein of TGF-β1 and TIMP-1 in liver were significantly reduced in effective dosage, but the levels of mRNA and protein of MMP- 13 in liver significantly increased in effective dosage. The results showed that compound Yinzhiku has significantly inhibit the development of liver fibrosis in rats induced by CCl4.

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What this paper is about

To investigate the effects of compound Yinzhiku on hepatic fibrosis in rats. The expression of mRNA and proteins of TGF-β1, MMP-13 and TIMP-1 were detected by RT-PCR and immunohistochemistry after liver fibrosis. The levels of mRNA and protein of TGF-β1 and TIMP-1 in liver were significantly reduced in effective dosage, but the levels of mRNA and protein of MMP- 13 in liver significantly increased in effective dosage. The results showed that compound Yinzhiku has significantly inhibit the development of liver fibrosis in rats induced by CCl4.

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Available abstract

To investigate the effects of compound Yinzhiku on hepatic fibrosis in rats. The expression of mRNA and proteins of TGF-β1, MMP-13 and TIMP-1 were detected by RT-PCR and immunohistochemistry after liver fibrosis. The levels of mRNA and protein of TGF-β1 and TIMP-1 in liver were significantly reduced in effective dosage, but the levels of mRNA and protein of MMP- 13 in liver significantly increased in effective dosage. The results showed that compound Yinzhiku has significantly inhibit the development of liver fibrosis in rats induced by CCl4.

Key concepts: Messenger RNA, CCL4, Immunohistochemistry, Hepatic fibrosis, Liver fibrosis, Fibrosis, Internal medicine, Medicine

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