Effect of Sinomenine Hydrochloride with iontophoresis on transdermal permeability

Objective To study the transdermal permeability of Sinomenine Hydrochloride and effected by ion-introduction.Method The transdermal permeability was made by skin in vitro in rabbits and Franz diffusion cells with Electric Therapeutic Equipment as apposition electrical field to use ion-introduction,the transdermal permeation rate of Sinomenine Hydrochloride injection was measured to compare the effect of the apposition electrical field affected on the transdermal permeability.Result The transdermal permeation rate of Sinomenine Hydrochloride was increased as time going on,which conformed to zero-order equation(R2=0.952 1),and the electrical field added was increased the transdermal absorption quantum,when the electrical field was 20 mA in 15 min,the transdermal absorption quantum was better.Conclusion Sinomenine Hydrochloride injection can be absorpted transdermally and be promoted by the electrical field,which provides an experimentation grounds for Sinomenine Hydrochloride injection using in ion-introduction in clinic.