Sinomenine hydrochloride ethosome preparation and its transdermal penetration

Objective To prepare sinomenine hydrochloride ethosome and evaluate the transdermal penetration of sinomenine hydrochloride taking ethosome as carrier.Methods Sinomenine hydrochloride ethosome was prepared with injection method and its appearance,particle size,and entrapment efficiency(EE) were analyzed.In transdermal test of mice,the transdermal behavior and accumulated permeation amounts of sinomenine hydrochloride in ethosome,liposomes,and water solution were compared by using Franz diffusion device.Results The shape of the sinomenine hydrochloride ethosome was spherical in an average diameter of 88.7 nm and the EE was 62.8%.The accumulated permeation amounts and permeation rates were significantly higher than those in liposomes and water solution.Conclusion The ethosome could greatly improve the transdermal penetration of sinomenine hydrochloride and it may be a potential carrier for transdermal use.