Impact of Allopurinol on Atherosclerosis Complicated with Hyperuricemia

Objective To investigate the impact of allopurinol on atherosclerosis complicated with hyperuricemia.Methods A total of 85 atherosclerosis patients complicated with hyperuricemia were selected in the Wuhuan Hospital of Xi' an from May 2013 to May 2014,and they were divided into control group( n = 42) and test group( n = 43) according to random number table. Patients of control group received conventional medical treatment,while patients of test group received allopurinol based on conventional medical treatment; both groups treated for 3 months. Systolic blood pressure, diastolic blood pressure,FBP,blood lipids index,indicators of liver and kidney function,hs-CRP,ABI and ba PWV were compared between the two groups,incidence of adverse reactions during treatment was recorded. Results No statistically significant differences of systolic blood pressure or diastolic blood pressure was found between the two groups before treatment( P 0. 05); while systolic blood pressure and diastolic blood pressure of test group were statistically significantly lower than those of control group after treatment( P 0. 05). No statistically significant differences of FBG,TC,TG,HDL or LDL was found between the two groups before treatment( P 0. 05); after treatment,FBG,TC,TG and LDL of test group were statistically significantly lower than those of control group, while HDL of test group was statistically significantly higher than that of control group( P 0. 05). No statistically significant differences of ALT,AST,BUN,Cr,GFR,UA or hs-CRP was found between the two groups before treatment( P 0. 05); after treatment,ALT,AST,BUN,Cr,UA and hs-CRP of test group were statistically significantly lower than those of control group,while GFR of test group was statistically significantly higher than that of control group( P 0. 05). No statistically significant differences of left- side ABI,right- side ABI or ba PWV was found between the two groups before treatment,nor was left- side ABI or right- side ABI between the two groups after treatment( P 0. 05),while ba PWV of test group was statistically significantly lower than that of control group after treatment( P 0. 05). No one of the two groups occurred any obvious adverse reactions during treatment. Conclusion Allopurinol can effectively reduce the blood pressure and blood glucose of atherosclerosis patients complicated with hyperuricemia,improve the blood lipid metabolism,liver and kidney function,reliere the severity of atherosclerosis and improvethe arterial elasticity.