Clinical significance detecting NT-proBNP,plasma cTnI and hsCRP in patients with chronic heart failure

Objective:To explore diagnostic and prognostic significance detecting N terminal pro brain natriuretic peptide(NT-proBNP),cardiac troponin I(cTnI) and high sensitive C-reactive protein(hsCRP) in patients with chronic heart failure(CHF).Methods:According to New York heart association(NYHA) cardiac classification,a total of 83 CHF patients were divided into NYHA class Ⅱ group(n=27),NYHA class Ⅲ group(n=29) and NYHA class Ⅳ group(n=27);according to NT-proBNP decreased 30% or not after treatment,each group was further divided into NT-proBNP decreasing 30% group and NT-proBNP decreasing ≤30% group.Left ventricular ejection fraction(LVEF),left ventricular end-diastolic dimension(LVEDd),levels of NT-proBNP,cTnI and hsCRP were measured in all patients at the beginning and 7d after admission.A total of 75 cases were followed up for 9～12 months to study relationship among NT-proBNP,cTnI,hsCRP and incidence of cardiac events.Results: As CHF was more severe,there were significant increase in levels of NT-proBNP,cTnI,hsCRP and LVEDd,and significant decrease in LVEF,P0.01 all;in NYHA class Ⅳ group,compared with NT-proBNP decreasing ≤30% group,there were significant decrease in levels of cTnI and hsCRP in NT-proBNP decreasing 30% group(P0.01).Compared with no cardiac events group on seventh day after admission,there were significant increase in levels of cTnI [(0.17±0.03) ng ml vs.(0.965±0.24) ng ml],hsCRP [(1.07±0.05) mg L vs.(6.97±0.12) mg L]and NT-proBNP [(253.54±57.40) pg ml vs.(4358.70±543.22) pg ml]in group with cardiac events(P0.01).Conclusion: NT-proBNP,cTnI and hsCRP possess important significance in diagnosis and evaluation of prognosis of chronic heart failure.