Expressions of BAG-1 and Bcl-2 proteins in bone marrow mononuclear cells from patients with acute leukemia

Aim:To explore the BAG-1 and Bcl-2 expressions in bone marrow mononuclear cells from patients with acute leukemia(AL).Methods:The expressions of BAG-1 and Bcl-2 in bone marrow mononuclear cells were detected by SP immunocytochemical staining assay in untreated AL group(112 cases),AL complete remission(AL-CR) group(57 cases),relapsing and refractory AL(RRAL) group(29 cases),and normal control group(20 cases).Results:There were significant differences in the positive expression rates of BAG-1 and Bcl-2 proteins among the 4 groups(χ2=61.795,37.866,P0.001),and the positive rates of the two proteins in untreated AL group and RRAL group were significantly higher than those in AL-CR group and normal control group(P0.001).In untreated group,there was a marked relation between the expression of BAG-1 and the number of WBC in peripheral blood or leukemic infiltration(χ2=16.336,19.289,P0.001),and BAG-1 positive rate was associated with Bcl-2(rP=0.587,P0.001).Conclusion:BAG-1 combined with Bcl-2 may play an important role in the pathogenesis and progression of AL.