Clinical significance of expression of P-glycoprotein and bcl-2 protein in acute leukemia

Objective:To study the clinical significance of the expression of p-glycoprotein(p-gp)and bcl-2 protein in acute leukemia(AL).Methods:The expression ratios of p-gp and bcl-2 in bone marrow cells from 151 patients with AL were detected by immunohistochemistry SABC-AP.Results:The expression of p-gp was higher in the patients with refractory/relapsed acute myelogenous leukemia than that of untreated patients with AML.There was no significant difference in the positive percentage of bcl-2 between refractory/relapsed ALL patients and the untreated patients.The higher expression of p-gp and bcl-2 were observed in M5 subtype of AML.The CR rate in the patients with p-gp positive was lower than that in the patients with p-gp-(P0.05).There was no significant difference in the CR rate between the patients with bcl-2 positive and those with bcl-2 negative(P0.05).The CR rate in the patients with p-gp positive and bcl-2 positive(7.5%)was lower than that in patients with p-gp-and bcl-2 negative(91.5%)(P0.01).Conclusion:The measurement of p-gp combined with bcl-2 may be more valuable to evaluate the prognosis of acute leukemia.