A clinical analysis of 88 patients with drug-induced liver disease

Objective To investigate the clinical features of drug-induced liver disease(DILD).Methods 88 patients with DILD admitted to our hospital from Jan.2001 to Dec.2007 were reviewed retrospectively.Results A variety of drugs were involved in causing liver disease.The common offending agents were antimicrobial agents(47.7%) and Chinese herb medicine(25%);61.4% was classified as hepatocellular type,20.1% as cholestatic type,and 18.2% as mixed type.The main clinical manifestations were fatigue,jaundice,anorexia,nausea and vomiting.The laboratory tests of liver functions showed increased levels of ALT,GGT and AKP.The patients were recovered in 76%,improved in 18.2%,and died in 1.1%.Conclusion A variety of drugs can induce liver disease,and a special attenion should be paid to Chinese herbal medicines,which were thought safety in the past,but found to cause liver injuries increasingly common.