A clinical analysis of 107 patients with drug-induced liver disease

Objective To improve the early diagnosis and treatment of drug-induced liver disease by summarizing its clinical features. Methods One hundred and seven cases of drug-induced liver disease admitted to our hospital from Jan 2000 to Dec 2006 were reviewed retrospectively. Results A variety of drugs could cause liver disease. The offending agents could be classified as follows:antimicrobial agents(including antituberculotic drugs) (30.84%), traditional Chinese herb medicine (18.69%),antipyretic, analgesic, and anti-inflammatory(7.48%),anticancer drugs (5.61%).And of 107 cases, 57.95% was classified as hepatocellular type, 23.36% as cholestatic type, and 18.69% as mixed type. The main clinical manifestations were fatigue, nausea, vomiting and jaundice. Most of 107 cases (89.72%) had better prognosis. Conclusions A variety of drugs can induce liver disease, and the clinical fatures are of no specificity. To control the drug indication strictly and monitor liver function should be effective measures for prevention.