The clinical research of noninvasive positive pressure ventilation in threatment of chronic obstructive pulmonary disease with acute exacerbation of respiratory failure

Objective To investigate the effect of noninvasive positive pressure ventilation(NIPPV) in threatment of chronic obstructive pulmonary disease with acute exacerbation of respiratory failure, aim to provide a reference for find an effective way in the clinical treatment of chronic obstructive pulmonary disease with acute exacerbation of respiratory failure. Methods From January to 2009 January 2013 in our hospital, chronic obstructive pulmonary disease with acute exacerbation of respiratory failure in 80 patients as an object of observation groups were treated anti-infectious, antispasmodic, expectorant, correct electrolyte imbalance and symptomatic and supportive cure. Treatment group while applying BiPAP Symchrony ventilator, through the nose and mouth mask for NIPPV treatment; control group was given low flow nasal cannula ventilation therapy. Observed and compared: 1)The clinical efficacy of two groups of patients; 2) Two groups of patients before and after ventilation ventilation 2 hours, 24 hours, ventilation therapy at the end of pH, PaO2, PaCO2, SaO2 changes. 3)Two groups of patients intubation and mechanical ventilation, mortality, average length of stay and complications that occur during treatment. Results After treatment, the total effective rate of the treatment group was 90.0%, was significantly higher than that of the control group(70.0%)(P 0.05). End of treatment, patients treated with pH, PaO2, SaO2, PaCO2 changed than before treatment, aeration after 2h, 24h after ventilation improved significantly within the group, the difference was significant(P 0.05). And in patients treated with pH, PaO2, SaO2, PaCO2 compared with the control group improved more significantly between the two groups, the difference was significant(P 0.05). Patients treated with intubation and mechanical ventilation rate of 5.0%, was significantly lower than the control group, the treatment group patients had a mean hospital stay was(11.7±3.9)d, was significantly shorter than the control group, the mortality rate in patients treated was 2.5%, was significantly less than the control group, and the difference was significant(P 0.05). Conclusion Noninvasive positive pressure ventilation in chronic obstructive pulmonary disease with acute exacerbation of respiratory failure can improve clinical outcomes, improve the patient's oxygen partial pressure and oxygen saturation, shorter hospital stays and lower mortality, lower rates of mechanical ventilation, should be popularized and applied.