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Immunohistochemical Study of Meningioma

Pla Air

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Abstract

Meningioma shows morphological heterogeneity in light microscopy.The histo-genesis of meningioma is uncertain.By the use of immunohistochemical staining(ABC and PAP methods).The distribution of Vimentin,Epithelial membrane anti-gen,Light weight cytokeratin,S-100 protein,Keratin and Carcinoembryonic antigenin 28 cases of meningiomas have been investigated.The results demonstrated that meningioma expressed the markers of both mesen-chymal and epithelial tissues.The observation that meningiomas contained both Vimentin filaments and themarkers of epithelial supported the concept of the so-called“meningothelial cell”asthe progenitor cell for menigiomas,exhibiting both epithelial and mesenchymal fea-tures.

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What this paper is about

Meningioma shows morphological heterogeneity in light microscopy.The histo-genesis of meningioma is uncertain.By the use of immunohistochemical staining(ABC and PAP methods).The distribution of Vimentin,Epithelial membrane anti-gen,Light weight cytokeratin,S-100 protein,Keratin and Carcinoembryonic antigenin 28 cases of meningiomas have been investigated.The results demonstrated that meningioma expressed the markers of both mesen-chymal and epithelial tissues.The observation that meningiomas contained both Vimentin filaments and themarkers of epithelial supported the concept of the so-called“meningothelial cell”asthe progenitor cell for menigiomas,exhibiting both epithelial and mesenchymal fea-tures.

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Available abstract

Meningioma shows morphological heterogeneity in light microscopy.The histo-genesis of meningioma is uncertain.By the use of immunohistochemical staining(ABC and PAP methods).The distribution of Vimentin,Epithelial membrane anti-gen,Light weight cytokeratin,S-100 protein,Keratin and Carcinoembryonic antigenin 28 cases of meningiomas have been investigated.The results demonstrated that meningioma expressed the markers of both mesen-chymal and epithelial tissues.The observation that meningiomas contained both Vimentin filaments and themarkers of epithelial supported the concept of the so-called“meningothelial cell”asthe progenitor cell for menigiomas,exhibiting both epithelial and mesenchymal fea-tures.

Key concepts: Vimentin, Immunohistochemistry, Meningioma, Cytokeratin, Keratin, Pathology, Staining, Mesenchymal stem cell

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