Experimental study of Anisodamine against hepatic ischemia-reperfusion injury

Objective To study the effect of Anisodamine on hepatic ischemia-reperfusion injury and its possible mechanism in rats.Methods The bile flow, levels of malondiadehyde(MDA) in the hepatic tissues were measured in hepatic ischemia-reperfusion injury in rats with or without administration of Anisodamine. The histological changes in hepatic tissues and the degree of neutrophil infiltration were also measured. Results As the liver reperfusion prolonged, the neutrophil infiltration degree was increasing. After administration of Anisodamine intravenously, the liver tissue MDA and the degree of neutrophil infiltration were significantly lower than those of untreated groups( P 0 01).But the bile flow was significantly higher than that of untreated groups( P 0 01).Conclusions The hepatic ischemia-reperfusion injury can be significantly protected with Anisodamine. The protective mechanism may be that Anisodamine inhibits the production of oxygen-derived free redicals. [