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2003•Di-Si Junyi Daxue xuebaoRequires access

Effect of bFGF on VEGF expression and biological behavior of marrow stromal cells

Hu Yun

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Abstract

AIM: To investigate the effects of basic fibroblast growth factor (bFGF) on vascular endothelial growth factor (VEGF) expression and the biological behavior of marrow stromal cells. METHODS: The marrow stromal cells of the femur of rabbits were procured and cultured. The samples were treated with different doses of bFGF and the control was not treated. Five days later, the effects were observed by histopathological analysis, cells multiplication, alkaline phosphatase activities detection, the computer analysis of bone clusters and the detection of ratio of VEGF positive cells. RESULTS: There was statistically significant difference between different dose groups in all the detection items and the results of treatment groups were all better than that of the control group. CONCLUSION: bFGF can stimulate both the multiplication and osteogenic potential of marrow stromal cells in a dose dependent manner and the best dose of bFGF is 1200 kU·L -1 .

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AIM: To investigate the effects of basic fibroblast growth factor (bFGF) on vascular endothelial growth factor (VEGF) expression and the biological behavior of marrow stromal cells. METHODS: The marrow stromal cells of the femur of rabbits were procured and cultured. The samples were treated with different doses of bFGF and the control was not treated. Five days later, the effects were observed by histopathological analysis, cells multiplication, alkaline phosphatase activities detection, the computer analysis of bone clusters and the detection of ratio of VEGF positive cells. RESULTS: There was statistically significant difference between different dose groups in all the detection items and the results of treatment groups were all better than that of the control group. CONCLUSION: bFGF can stimulate both the multiplication and osteogenic potential of marrow stromal cells in a dose dependent manner and the best dose of bFGF is 1200 kU·L -1 .

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Available abstract

AIM: To investigate the effects of basic fibroblast growth factor (bFGF) on vascular endothelial growth factor (VEGF) expression and the biological behavior of marrow stromal cells. METHODS: The marrow stromal cells of the femur of rabbits were procured and cultured. The samples were treated with different doses of bFGF and the control was not treated. Five days later, the effects were observed by histopathological analysis, cells multiplication, alkaline phosphatase activities detection, the computer analysis of bone clusters and the detection of ratio of VEGF positive cells. RESULTS: There was statistically significant difference between different dose groups in all the detection items and the results of treatment groups were all better than that of the control group. CONCLUSION: bFGF can stimulate both the multiplication and osteogenic potential of marrow stromal cells in a dose dependent manner and the best dose of bFGF is 1200 kU·L -1 .

Key concepts: Stromal cell, Basic fibroblast growth factor, Bone marrow, Alkaline phosphatase, Vascular endothelial growth factor, VEGF receptors, Biology, Growth factor

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