Effects of tirofiban on left ventricular function after percutaneous coronary intervention in patients with high-risk non-ST-elevation myocardial infarction

Objectives To investigate the effects of tirofiban on left ventricular function and endothelial function after percutaneous coronary intervention(PCI)in patients with high-risk non-ST-elevation myocardial infarction(NSTEMI) and evaluate mechanism of tirofiban.Methods One hundred high-risk NSTEMI patients were randomly divided into two groups.Experimental group(50 cases) were treated with tirofiban before PCI,and control group(50 cases) were treated without tirofiban.Basic clinical information and angiographic characteristics before and after PCI and major adverse cardiac events(MACE) rate were collected and analyzed.Parameters of left ventricular function and flow-mediated dilation(FMD) were determined during 7 days and 90 days after PCI.Results Compared with control group,isovolumic relaxation time,MACE rate in experimental group were reduced(P0.05),while thrombolysis in myocardial infarction(TIMI) 3 grade proportion,E/A,left ventricular ejection fraction and FMD were increased (P0.05).Conclusions Tirofiban may improve TIMI flow of the infarction related artery in patients with NSTEMI; furtherly it has positive effect on left ventricular function and endothelial function,and reduces the incidence of MACE.