Effect of tirofiban on the prognosis of patients with diabetes mellitus accompanied with acute ST elevation myocardial infarction who undergoing primary percutaneous coronary artery interventional therapy

Objective:To evaluate the effect of glycoprotein Ⅱb/Ⅲa receptor blockers tirofiban on prognosis of patients with diabetes mellitus accompanied with acute ST elevation myocardial infarction who undergoing primary percutaneous coronary artery interventional therapy(PCI).Method:97 patients with acute ST-segment elevation myocardial infarction accompanied with diabetes mellitus admitted in our hospital to receive PCI were divided into tirofiban group(n=47) and control group(n=50),according to whether tirofiban was used in the operation.All patients were measured the indices of left ventricular end diastolic volume index(LVEDVI),left ventricular end systolic volume index(LVESVI),and left ventricular ejection fraction(LVEF) after PCI.Postinfarction angina pectoris,heart failure,cardiogenic shock and case fatality rate in hospital were compared in two groups.Result:The left ventricular volume was decreased,but LVEDVI[(65.2±5.4)ml/m2 vs(68.3±5.7)ml/m2,P0.05],LVESVI[(31.5±4.2)ml/m2 vs(35.6±3.7)ml/m2,P0.05] and LVEF [(0.52±0.04)% vs(0.48±0.03)%,P0.05]were increased in tirofiban group at 3 months after PCI.The incidence of postinfarction angina pectoris,heart failure,cardiogenic shock and case fatality rate in hospital were lower in tirofiban group than those in control group(P0.05).Conclusion:Application of tirofiban in patients with diabetes mellitus accompanied with acute ST elevation myocardial infarction who undergoing primary PCI could improve the clinical course and prognosis of patient.