The Expression and Clinical Significance of Survivin in Gallbladder Carcinoma

Objective To investigate the expression of Survivin in gallbladder carcinoma and its relation to development of the carcinoma.Methods The expression of Survivin in gallbladder carcinoma was detected by S-P immunohistochemical staining,20 cases of chronic cholecystitis were collected as the controls.Results ①The positivity rate of Survivin in gallbladder carcinoma increased significantly.②In metastasis or low differentiation there was higher expression of Survivin.③There was significant difference in survival time between patients with Survivin(+)and Survivin(-).Conclusions The detection of Survivin may be useful in assessing the development of the cancer,judging prognosis and eventually render a possible target for novel therapeutic strategies.