Effect of levofloxacin,amoxicillin and omeprazole triad system as rescue therapy for Helicobacter pylori infection

Objective To evaluate the effect of rescue therapy for eradicating Helicobacter pylori(Hp) with levofloxacin amoxicillin and omeprazole triad system.Methods Fifty patients with Helicobacter pylori infection were randomized divided treatment group and control group,25 patients of treatment group treated with omeprazole 20 mg,levofloxacin 20 mg,amoxicillin 1 000 mg,and 25 patients of control group treated with collodial bismuth subcitrate 200 mg,omeprazole 20 mg,amoxicillin 1 000 mg,clarithromycin 500 mg bid for 7 days.The 14C-urea breath test(UBT)was performed to evaluate the success of Hp eradication,at least four weeks after completion of therapy.Results By intention-to-treat(ITT) analysis and per-protocol(PP) analysis,the rates of eradication of H.pylori of treatment group were 76.00%(19/25) and 82.61%(19/23) respectively.The rates of eradication of control group were 60.00%(15/25) and 68.18%(15/22) respectively,which were lower significantly than that of treatment groups(P0.05).Conclusion Levofloxacin,amoxicillin and omeprazole triad system as rescue therapy has a satisfactory eradicating rate for previous treatment failure of H.pylori infection.