The Relationship between Helicobacter Pylori and Gastric Carcinoma and Gastric Precancerous Lesion

Objective To investigate H pylori infection in gastric carcinoma and precancerous lesion,for example,atrophic gastritis?intestinal metaplasia?dysplasia,and study the possible relationship between H pylori infection and gastric carcinoma.Methods Stomach mucosal biopsies were obtained from 333 patients.Pathology and H pylori infection were examined simultanously.H pylori infection was diagnosed by rapid urease test?histology and polymerase chain reaction.Among 333 patients,there were 89 of atrophic gastritis?64 of intestinal metaplasia?47 of dysplasia?30 of gastric carcinoma and 103 of dyspepsia controls.Results The positive rate of H pylori infection was higher in atrophic gastritis (79.3%) and intestinal metaplasia (81.3%).Compared with dyspepsia (61.2%) there was significant stastistical difference with P 0.01, P 0.01,respectively.The positive rate of H pylori infection was lower in dysplasia (72.3%) and gastric carcinoma (40%).Conclusions These results suggust that H pylori infection is associated with atrophy and intestinal metaplasia.On the contrary,the positive rate of HP infection shows descending trend in dysplasia and gastric carcinoma.H pylori infection involved mainly the early stage of precancerous lesion,it plays a causal role in the chain of events leading to cancer of the stomach.