2009•Unpublished venueRequires access
EFECT OF ATORVASTATIN ON MCP-1 IN RATS WITH DIABETIC NEPHROPATHY
Zhao Wang
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Abstract
Objective:To explore the protective mechanism of Atorvastatin on kidneys indiabetic rats by investigating the effects of Atorvastatin on MCP-1 in rats with diabetic nephropathy.Methods:A total of 24 male SD rats induced by streptozocin were randomly divided into 3 groups,normol control,diabetes and dibetes treated by atorvastatin.24-hour urine protein were measured by automatic biochemistry analyzer and Expression of MCP-1 were detected by immunohistochemical staining.Results:24-hour urine protein in diabetic rats were significantly higher than those in normal rats (P0.01),Atorvastatin treatment significantly inhibited activation of MCP-1(P0.05),decreased urine protein excretion.Conclusion:Atorvastatin exerted protective effect on diabetic nephropathy,Which is probably one of the mechanisms that decreased the expression of MCP-1.