16-28 weeks fetal gestational umbilical cord blood beta Mediterranean anemia genes and their hemoglobin electrophoresis,RBC parameter variation analysis

Objective: To study the red blood cell parameters and capillary electrophoresis and β-hemoglobin gene to detect anemia in the prenatal diagnosis of β thalassemia in the complementary role.Methods: 210 pregnant and 16 to 28 weeks of fetal cord blood samples according to determination of β-thalassemia genotypes were divided into 4 groups,4 groups of blood results mean corpuscular volume(MCV),mean corpuscular hemoglobin(MCH),mean corpuscular hemoglobin concentration(MCHC) and hemoglobin A(HbA%),and other parameters were analyzed.Results: In Group MCV,MCH,MCHC compared with results of other groups no significant difference(P0.05);but HbA(%) results in the other groups were lower than the control group,the difference was statistically significant(P0.05).Conclusion: 16-28 weeks pregnant fetal cord blood MCV,MCH and MCHC detection of β-thalassemia prenatal diagnosis of little value,and cord blood capillary electrophoresis and β-hemoglobin gene and detection of anemia is to have a good complementary.