Efficacy and toxicity of pemetrexed or vinorelbine plus cisplatin in treatment of patients with adenocarcinoma of lung

Objective:To observe the efficacy and toxicity of pemetrexed or vinorelbine plus cisplatin in treatment of patientswith adenocarcinoma of lung.Methods:The 53 cases of advanced adenocarcinoma lung were divided into vinorelbine plus cisplatin group(NC= 27) and pemetrexed plus cisplatin group(PC group) in 29 cases.NC group:vinorelbine 25 mg/m2,days 1,8;cisplatin 25 mg/m2,2 to 4 days.PC group:pemetrexed 500 mg/m2,d day 1;cisplatin 25 mg/m2,2 to 4 days,every 3 weeks for a period of repeated,two cycles were evaluated.Results:Altogether 53 patients were evaluated.The effective rate in NC group was 41.67% and in PC group was 51.72%.The effective rate between the two groups was no significant difference(P0.05).The main toxicity vasculitis in NC group was 37.50% lower than the PC group 6.90%(P0.05).Other toxicity were hematological toxicity and gastrointestinal reactions,including nausea,vomiting,and can be tolerated.Conclusions:Pemetrexed plus cisplatin had the effective activity as vinorelbine plus cisplatin in treatment of patients with adenocarcinoma of lung,and they appeared to be more-tolerated.It can be a choice of drug therapy for adenocarcinoma of lung.