Chemical constituents from leaves of Elsholtzia rugulosa

Objective To study the chemical constituents from the leaves of Elsholtzia rugulosa.Methods Compounds were isolated and purified by silica gel column and Sephadex LH-20 chromatography.Their chemical structures were identified by spectral data.Results Twelve compounds were isolated,purified,and identified as:apigenin-7-O-β-D-glucopyranoside (Ⅰ),luteolin-7-O-β-D-glucopyranoside (Ⅱ),acacetin-7-O-β-D-glucopyranoside (Ⅲ),luteolin-7-O-(6″-acetyl)-β-D-glucopyranoside (Ⅳ),benzyl alcohol-β-D-glucopyranoside (Ⅴ),prunasin (Ⅵ),β-sitosterol (Ⅶ),betulinic acid (Ⅷ),corosolic acid (Ⅸ),maslinic acid (Ⅹ),apigenin (Ⅺ) and luteolin (ⅩⅡ).Conclusion Compounds Ⅰ,Ⅲ,Ⅳ,Ⅸ,and Ⅹ are obtained from this plant for the first time.