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2008•Chinese Journal of Breast DiseaseRequires access

Research of the expressions of cyclooxygenase-2 and vascular endothelial growth factor and their effects on tumor angiogenesis in human breast cancer

Yang Ying-hon

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Abstract

Objective To study the expressions of cyclooxygenase-2(COX-2) and vascular endothelial growth factor(VEGF) and their effects on tumor angiogenesis in human breast carcinoma.Methods The expressions of COX-2 and VEGF were detected in 30 cases of primary breast carcinoma and 20 samples of normal breast tissue by immunohistochemical method.The tumor micrangium was also examined using CD34 staining.Results The expression rate of COX-2 and VEGF in breast carcinoma tissue was 70.0%(21/30)and 56.7%(17/30)respectively,with significant difference compared with the nomal breast tissue.A significant correlation was found between COX-2 and VEGF expressions.Both COX-2 and VEGF were significantly correlated with tumor angiogenesis.Conclusion Both COX-2 and VEGF are related to tumor angiogenesis in breast cancer.

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What this paper is about

Objective To study the expressions of cyclooxygenase-2(COX-2) and vascular endothelial growth factor(VEGF) and their effects on tumor angiogenesis in human breast carcinoma.Methods The expressions of COX-2 and VEGF were detected in 30 cases of primary breast carcinoma and 20 samples of normal breast tissue by immunohistochemical method.The tumor micrangium was also examined using CD34 staining.Results The expression rate of COX-2 and VEGF in breast carcinoma tissue was 70.0%(21/30)and 56.7%(17/30)respectively,with significant difference compared with the nomal breast tissue.A significant correlation was found between COX-2 and VEGF expressions.Both COX-2 and VEGF were significantly correlated with tumor angiogenesis.Conclusion Both COX-2 and VEGF are related to tumor angiogenesis in breast cancer.

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Available abstract

Objective To study the expressions of cyclooxygenase-2(COX-2) and vascular endothelial growth factor(VEGF) and their effects on tumor angiogenesis in human breast carcinoma.Methods The expressions of COX-2 and VEGF were detected in 30 cases of primary breast carcinoma and 20 samples of normal breast tissue by immunohistochemical method.The tumor micrangium was also examined using CD34 staining.Results The expression rate of COX-2 and VEGF in breast carcinoma tissue was 70.0%(21/30)and 56.7%(17/30)respectively,with significant difference compared with the nomal breast tissue.A significant correlation was found between COX-2 and VEGF expressions.Both COX-2 and VEGF were significantly correlated with tumor angiogenesis.Conclusion Both COX-2 and VEGF are related to tumor angiogenesis in breast cancer.

Key concepts: Angiogenesis, Breast carcinoma, Vascular endothelial growth factor, Breast cancer, Immunohistochemistry, CD34, Medicine, Pathology

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Research of the expressions of cyclooxygenase-2 and vascular endothelial growth factor and their effects on tumor angiogenesis in human breast cancer — Research Paper | ScholarLens