Clinical trial of the valsartan/amlodipine compound preparations and the single of two drugs for treatment of moderate and severe hypertension

Objective To evaluate the clinical efficacy and safety of valsartan / amlodipine compound preparations versus amlodipine combined with valsartan for treatment of moderate and severe hypertension.Methods One hundred and twenty subjects with hypertension( BP ≥160 /100 mm Hg) were recruited from our hospital in the outpatient service department. The recruited 120 cases were randomized divided into treatment group and control group with each group of 60 cases. Patients in the treatment group were given valsartan / amlodipine compound preparations( 80 /5) 85 mg one pil per day for 8 weeks and patients in the control group were given amlodipine 5 mg qd po plus valsartan 80 mg qd po with a treatment period of 8 weeks. The blood pressure and adverse drugs reaction( ADR) between the two groups were recorded and compared. Results The blood pressure was significant decreased in both of two groups after taken the medicine but no statistical difference between the two groups was found( P 0. 05). And ADR in the two groups was also no statistical difference( P 0. 05). Conclusion The monolithic compound antihypertensive valsartan / amlodipine was reliable and similar to that of monolithic joint valsartan amlodipine.