Application of serum C-reactive protein in discrimination of neonatal blood culture contamnation

Objective:To investigate and evaluate the application value about c-reactive protein(CRP) level in blood culture bacteria contamination from neonatal.Methods: 2859 hospitalized newborn babies were collected for blood culture and serum CRP detection.Cases with blood culture positive or CRP level increase were carried out a second blood culture,then the relationship between CRP results and various pathogenic infections was analyzed.Results: The blood culture positive rate was 9.3% in 2859 cases,with 61.0% of gram-positive,the primary bacteria was staphylococcus epidermidis about 63.2%.Gram-negative bacteria accounted for 39.0% with lwoffii acinetobacter primarily,accounting for 51.0%.In blood culture positive specimens,when serum CRP8 mg/L,gram-positive bacteria accounted for 44.6%,while gram-negative bacteria accounted for 14.2%,the difference between them had statistical significance(P0.05),and the coincidence rates of the two blood culture positive in gram-positive bacteria and gram-negative bacteria were 1.5% and 20.0%,which were 80.0% and 100% when CRP≥60 mg/L.Conclusion: The detection of serum CRP level can help identify whether the blood culture is positive pathogenic bacteria or pollution bacteria,avoiding unnecessary use of clinical antimicrobial drugs.