The impact of leflunomide on diabetic nephropathy rat NF-κβ, VEGF and TGF-β expression

Objective To explore the impact of leflunomide on diabetic nephropathy rat NF-κβ,VEGF and TGF-β expression.Methods Through the establishment of a rat model of diabetic nephropathy,studies of leflunomide on NF-κβ,VEGF and TGF-β expression.Results Successfully established a rat model of diabetic nephropathy,studies have shown that leflunomide can down the rats with diabetic nephropathy expression of NF-κβ、VEGF and TGF-β.Conclusion Leflunomide can be an ideal drug for the treatment of diabetic nephropathy,its therapeutic mechanism may be related to lowered NF-κβ,VEGF and TGF-β,specific mechanism needs further study.