Community-associated methicillin-resistant Staphylococcus aureus molecular study

Objective The research of the molecular biology characteristics for community associated methicillin-resistant Staphylococcus aureus(CA-MRSA),provide a basis for clinical prevention and control of CA-MRSA infection.Methods Collected five methicillin-resistant Staphylococcus aureus between January 2007 to September 2008,Using PCR for Staphylococcus aureus gene cassette(SCCmec) typing and multi-locus sequence analysis(MLST) and Staphylococcus A protein(SPA) typing.Results The three SCCmecⅣ of 5 CA-MRSA and another two was SCCmecⅤ type.MLST typing of SCCmecⅣ type strains were ST59-type and SCCmecⅤ type strains were ST7-type and Another one failed to MLST type.SPA genotyping of the three SCCmecⅣ strain attributed to the t437,the other two were t163 and t796.Conclusion Prevalent CA-MRSA infection mainly carry the gene-based SCCmecⅣ strain.This study shows that exists CA-MRSA infection in the clinical,so should pay a close attention,make perfect job of monitoring the CA-MASA infection.