Observation of therapeutic effects of three drugs on paroxysmal atrial fibrillation

Objective To investigate the efficacy and safety of propafenone,admiodarane,metoprolol and tartrate capsules(Betaloc) in treating and preventing of paroxysmal atrial fibrillation(PAF).Methods 80 patients with atrial fibrillation were randomly divided into propafenone(n=32),admiodarane(n=28) and metoprolol group(n=20).Results The recovery rates within 48 hours after treatment in propafenone,admiodarane and metoprolol group were 72%,75% and 65% respectively.No significant difference was found in three groups(P0.05).There was no significant difference among different age groups(P0.05).The occurrence rates of adverse reactions in the propafenone,admiodarane and metoprolol group were 16%,14% and 15% respectively.There was no significant difference(P0.05).No serious side effect or arrhythmia was found.Conclusion Three drugs are effective and relatively safe in the treatment and prevention of the relapse of PAF.