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2006•Chinese Polymer BulletinRequires access

A Systemic Comparison between PNA Probe and DNA Probe

Chendong Jin

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Abstract

Peptide nucleic acid(PNA) with peptide linkages as its backbone is a brand new kind of compounds which are developed in recent years.It is an analog of DNA in molecular structure.PNA can hybridize DNA and RNA specifically,thus it can be used as probes.Compared with traditional DNA probes,PNA probes enjoy higher hybrid_stabilization,better specificity,and it can hybridize target substance under low salt ion concentration.This paper makes a systemic comparison between PNA probe and DNA probe in the aspects of probes preparation,hybridization specificity,hybridization kinetics and biosensors applications.

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What this paper is about

Peptide nucleic acid(PNA) with peptide linkages as its backbone is a brand new kind of compounds which are developed in recent years.It is an analog of DNA in molecular structure.PNA can hybridize DNA and RNA specifically,thus it can be used as probes.Compared with traditional DNA probes,PNA probes enjoy higher hybrid_stabilization,better specificity,and it can hybridize target substance under low salt ion concentration.This paper makes a systemic comparison between PNA probe and DNA probe in the aspects of probes preparation,hybridization specificity,hybridization kinetics and biosensors applications.

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Available abstract

Peptide nucleic acid(PNA) with peptide linkages as its backbone is a brand new kind of compounds which are developed in recent years.It is an analog of DNA in molecular structure.PNA can hybridize DNA and RNA specifically,thus it can be used as probes.Compared with traditional DNA probes,PNA probes enjoy higher hybrid_stabilization,better specificity,and it can hybridize target substance under low salt ion concentration.This paper makes a systemic comparison between PNA probe and DNA probe in the aspects of probes preparation,hybridization specificity,hybridization kinetics and biosensors applications.

Key concepts: Peptide nucleic acid, Hybridization probe, DNA, Nucleic acid, Molecular probe, Nucleic acid thermodynamics, Biosensor, Peptide

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