Effect of JiangQian I on Blood-lead and Ability of Learning and Memory in Rats Exposed to Low Level Lead

Objective:To investigate the effects of JiangQian Ⅰ on blood-lead and ability of learning and memory in rats exposed to low level lead and explore its possible mechanism.Methods:50 Wistar rats were divided into five groups randomly,which named model group,EDTA group,JiangQian Ⅰ low dose group,middle dose group and high dose group.Model rats which poisoning of lead were prepared by drinking water with lead acetate.Then ten rats were choused randomly from each group to measure the lead content in blood and nitric oxide synthase(NOS) activity in the hippocampus.They were treated for 30 days and the same target were measured too.All rats were taken Y maze to test the ability of leaning and memory which indicated the lead-induced injuries to nervous.Result:After 30 days treatment with JiangQian Ⅰ,The lead content in blood of each treatment group was significantly lower than the model group and the NOS activity in hippocampus was higher than the model group(except JiangQian Ⅰ low dose group)(P0.05),Y maze test indicated that the retain percent of learning and memory of three groups treated with JiangQian Ⅰ was obviously increased than the model group.Futhermore,the effect of two groups treating with JiangQian Ⅰ middle dose or high dose is better than the group treating with JiangQian Ⅰ low dose(P0.05).Conclusion:JiangQian Ⅰ has curative effect to rats poisoning of lead and can amend the impairment of learning and memory.JiangQian Ⅰ can increase the NOS activity in hippocampus,which may be the mechanism of it.