Effects of Granule taken from lead on nitric oxide synthase and ability of learning and memory in brains of rats exposed to low level lead.

【Objectives】 To provide basis for evaluating curative effect of Granule taken from lead and the role of it in the protection against injuries to nervous system,with ability of learning and memory and the changes of NOS activity in different brain regions. 【Methods】 60 Wister rats(80～100 g) were divided into 6 groups(n=10 each) randomly.After models of rats exposed to low level lead were established,one group of rats were treated with CaNa2EDTA 10 mg/(kg ·d) for 30 days Three groups were lavaged with high,medium,low dose of Granule taken from lead 5,10,20 g/(kg·d).The last two groups were lavaged with equal distilled.Effects of Granule taken from lead on ability of learning and memory were observed with Y maze and that on nervous biochemistry were evaluated with NOS activity in different brain regions. 【Results】 ①Y maze test indicated that the ability of learning and memory in brains of rats exposed to low level lead was significantly lower than that of normal rats(P0.01).The retain percent of learning and memory of the three groups treated by Granule taken from lead was obviously increased,which was higher than that of positive control group and EDTA group.②NOS activity in cerebral cortical and cerebellums was obviously decreased and that in hippocampus had tendency of descent in brains of rats exposed to low level lead.NOS activity in different brain regions of rats treated by Granule taken from lead was increased in different degree. 【Conclusion】 It indicated that Granule taken from lead can amend the impairment of learning and memory in rats exposed to low level lead.