Obsevation of Clinicopathology on 10 cases of Anaplastic Large Cell Lymphoma

Objective:Purpose To explore the histological immunohistochemical characters and prognosis of anaplastic large cell lymphoma(ALCL).Methods Histology and immunohistochemical markers of 10 ALCL cases were analyzed and the correlated literature was reviewed.Results The ALCL of 10 patients had 9:1 male/fe-male ratio with an average age of 38.7.4 cases were located in the lymph node of neck,2 in small intestine,2 in epicranium,1 in mediastina and 1 in bronchus.The ALCL showed distinctive morphological characters.The tumors were mainly composed of large and pleomorphic cells with abundant cytoplasm.The nuclei were large and irregular with shape of twist horseshoed and wreath like.Multiple nuclei or huge nuclei were seen sometimes.All 10 cases expressed CD30and partly expressed CD3,EMA and CD45RO.All cases were negative for AE1/AE3,CD20,HMB45,S100,CD68,CD15.Conclusions ALCL is extremely rare.It is necessary to differentiate from other type of tumors such as the Hodgkin lymphoma,diffuse large B cell lymphoma,poor differentiated carcinomas and malignant melanoma.