2006•Journal of Apoplexy and Nervous DiseasesRequires access

Effect of polygonum multiflorum thumb on apoptosis of hippocampal neurons induced by Aβ

Xia Jian

Abstract

Objective To study the effect of Polygonum Multiflorum Thumb (PMT) on apoptosis of hip-pocampal neurons induced by Aβ1-40. Methods The AD (Alzheimer disease) model rats are established by injection of amyloid-beta protein into right hippocampus of rats and are fed with PMT. Learning and memory ability was studied by Y-electric maze at different time. The expression of apoptosis related protein Bax in rats'hippocampus were studied by immunohistochemistry method. Results The experiment showed that the learning and memory a-bilities were worse,the expression of Bax was increased in AD model rats. The expression of Bax was decreased in the PMT's rats. Learning and memory abilities were better than those of the AD model rats,but were also worse than the control group (P0. 01). Conclusion The injection of Aβ1-40 into hippocampus of rats can cause the loss of learning and memory abilities, which is related the up-expression of Bax. PMB is found to improve learning and memory abilities and may be related to its inhibition of expression of Bax.

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Key concepts: Hippocampus, Apoptosis, Hippocampal formation, Polygonum, Immunohistochemistry, Amyloid beta, Neuroscience, Internal medicine