Effect of naoling docoction on hippocampal neurons apoptosis in rats with alzheimer' disease

[Objective] To investigate the effect of Nao ling decoction to the expression apoptosis related gene bcl-2 and bax of the hippocampus cells in rats with Alzheimer's disease and it's behavior of learning and memory.[Method] The AD model of rats was established by be given D-galactose,ip;and Alcl3,ig,Y-electric morris maze was used to test learning and memory;Distilled the total RNA and the expression of bcl-2 and bax by using the methods of Reverse Transcription-Polymerase Chain Reaction and agarose gelelectrophoresis were measured.[Result] The combined use of D-galactose and Alcl3 induced some alterations in rats,such as learning and memory impairment,The Nao ling decoction can enhance the expression of bcl-2 gene,reduce the expression of bax gene injured hippocampal neurons.[Conclusion] The Naoling decoction enchanced the ratio of bcl-2/bax,to restrain the apoptosis of the hippocampal neurons,improve the leaning and memory of the AD' rats.