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2011•The Chinese Journal of Clinical PharmacologyRequires access

Clinical evaluation of tumor markers in the prediction of breast cancer recurrence and metastasis

Tao Si-qing

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Abstract

Objective To investigate the clinical evaluation of tumor markers CA15-3 and CA125 in the prediction of breast cancer recurrence and metastasis.Methods Using enzyme-linked immunosorbent assay(ELISA) to determine serum CA15-3 and CA125 levels of 167 breast cancer patients before and after surgery as well as 80 healthy women.Results Serum CA15-3 and CA125 levels are significantly higher in stage Ⅲ and Ⅳ patients than stage Ⅰ and Ⅱ patients and healthy women.The CA15-3 levels increase evidently in patients of recurrence and metastasis.There is no difference between stage I and Ⅱ patients and healthy women.Conclusion Tumor markers CA15-3 and CA125 have important application in the evaluation of clinical stages and the prediction of recurrence and metastasis,however,they have no effectiveness in early diagnosis.

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What this paper is about

Objective To investigate the clinical evaluation of tumor markers CA15-3 and CA125 in the prediction of breast cancer recurrence and metastasis.Methods Using enzyme-linked immunosorbent assay(ELISA) to determine serum CA15-3 and CA125 levels of 167 breast cancer patients before and after surgery as well as 80 healthy women.Results Serum CA15-3 and CA125 levels are significantly higher in stage Ⅲ and Ⅳ patients than stage Ⅰ and Ⅱ patients and healthy women.The CA15-3 levels increase evidently in patients of recurrence and metastasis.There is no difference between stage I and Ⅱ patients and healthy women.Conclusion Tumor markers CA15-3 and CA125 have important application in the evaluation of clinical stages and the prediction of recurrence and metastasis,however,they have no effectiveness in early diagnosis.

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Available abstract

Objective To investigate the clinical evaluation of tumor markers CA15-3 and CA125 in the prediction of breast cancer recurrence and metastasis.Methods Using enzyme-linked immunosorbent assay(ELISA) to determine serum CA15-3 and CA125 levels of 167 breast cancer patients before and after surgery as well as 80 healthy women.Results Serum CA15-3 and CA125 levels are significantly higher in stage Ⅲ and Ⅳ patients than stage Ⅰ and Ⅱ patients and healthy women.The CA15-3 levels increase evidently in patients of recurrence and metastasis.There is no difference between stage I and Ⅱ patients and healthy women.Conclusion Tumor markers CA15-3 and CA125 have important application in the evaluation of clinical stages and the prediction of recurrence and metastasis,however,they have no effectiveness in early diagnosis.

Key concepts: Medicine, Breast cancer, Metastasis, Oncology, Stage (stratigraphy), Internal medicine, CA15-3, Cancer

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