ScholarLens Back to search
2006•Journal of Preventive Medicine of the Chinese People's Liberation ArmyRequires access

EFFECT OF EMP ON THE EXPRESSION OF SYNAPTIC PLASTICITY-ASSOCIATED PROTEINS IN RAT HIPPOCAMPUS

Shaochen Liu

Open publisher page 0 citations

Abstract

Objective To explore the expression of synaptic plasticity-associated proteins in hippocampus of rats exposed to EMP.Methods Wistar rats were exposed to EMP(6×10~4V·m~(-1)) and the expression of brain-derived neurotrophic factor(BDNF) and neural celladhesion molecule(NCAM) proteins in hippocampus were detected with Western blot analysis.Results The level of BDNF increased 25.8% more in exposed group than in control group 6 h after EMP exposure(P0.05),then decreased gradually.7 d after exposure BDNF rose again(32.2% more in exposed group than in control group,P0.05).The expression of NCAM protein increased 8.1% more in exposed group than in control group 6～12 h after exposure(P0.05),and decreasod 10.8% more 3 d after exposure(P0.05),and again increased 14.1% more 7 d after exposure(P0.05).Conclusion Up-regulation of BDNF and NCAM may play a role in positive alteration of synaptic plasticity during the early stage after EMP irradiation.

About this research paper

What this paper is about

Objective To explore the expression of synaptic plasticity-associated proteins in hippocampus of rats exposed to EMP.Methods Wistar rats were exposed to EMP(6×10~4V·m~(-1)) and the expression of brain-derived neurotrophic factor(BDNF) and neural celladhesion molecule(NCAM) proteins in hippocampus were detected with Western blot analysis.Results The level of BDNF increased 25.8% more in exposed group than in control group 6 h after EMP exposure(P0.05),then decreased gradually.7 d after exposure BDNF rose again(32.2% more in exposed group than in control group,P0.05).The expression of NCAM protein increased 8.1% more in exposed group than in control group 6～12 h after exposure(P0.05),and decreasod 10.8% more 3 d after exposure(P0.05),and again increased 14.1% more 7 d after exposure(P0.05).Conclusion Up-regulation of BDNF and NCAM may play a role in positive alteration of synaptic plasticity during the early stage after EMP irradiation.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To explore the expression of synaptic plasticity-associated proteins in hippocampus of rats exposed to EMP.Methods Wistar rats were exposed to EMP(6×10~4V·m~(-1)) and the expression of brain-derived neurotrophic factor(BDNF) and neural celladhesion molecule(NCAM) proteins in hippocampus were detected with Western blot analysis.Results The level of BDNF increased 25.8% more in exposed group than in control group 6 h after EMP exposure(P0.05),then decreased gradually.7 d after exposure BDNF rose again(32.2% more in exposed group than in control group,P0.05).The expression of NCAM protein increased 8.1% more in exposed group than in control group 6～12 h after exposure(P0.05),and decreasod 10.8% more 3 d after exposure(P0.05),and again increased 14.1% more 7 d after exposure(P0.05).Conclusion Up-regulation of BDNF and NCAM may play a role in positive alteration of synaptic plasticity during the early stage after EMP irradiation.

Key concepts: Hippocampus, Synaptic plasticity, Neurotrophic factors, Neural cell adhesion molecule, Western blot, Neuroplasticity, Internal medicine, Endocrinology

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
EFFECT OF EMP ON THE EXPRESSION OF SYNAPTIC PLASTICITY-ASSOCIATED PROTEINS IN RAT HIPPOCAMPUS — Research Paper | ScholarLens