Clinical distribution of Acinetobacter baumannii and change of drug resistance from 2007 to 2011

OBJECTIVE To understand the infection and drug resistance change of Acinetobacter baumannii so as to provide theoretical basis for rational use of antibiotics and prevent and reduce the incidence of nosocomial infections.METHODS A retrospective analysis was performed for the sources,the distribution and results of the drug susceptibility testing of A.baumannii clinical specimens obtained from Jan.2007to Dec.2011;the drug resistance was determined with K-B method.RESULTS A total of 2 762strains of A.baumannii were isolated from 2007to 2011in our hospital.The main specimens were sputum(1 866strains),the constituent ratio was 67.56%;these strains mainly distributed in ICU,with high constituent ratio every year.The drug resistance to 13kinds of common antibiotics increased as the time passed.The drug resistance to cefperazone-sulbactam,meropenem,and imipenem were respectively 1.15%,8.02%,4.01%in 2007,and 19.54%,75.69%,76.85%in 2011.Totally 1 382 strains of multidrug-resistant A.baumannii(MDRAB)have been isolated with the detection rate of 50.04%,and 1 208strains of pandrug-resistant A.baumannii(PDRAB)have been isolated with the detection rate of 43.74%. CONCLUSIONThe isolation rate and the drug resistance rate of the A.baumannii strains increase year by year in the clinical departments,and the strains show high multidrug-resistance and pandrug-resistance.