ScholarLens Back to search
2009•Modern Practical MedicineRequires access

The gene expression and its clinical significance of breast cancer resistance protein (BCRP) and MDR1 in patients with non-hodgkin lymphoma

Ningning Wu

Open publisher page 0 citations

Abstract

Objective To investigate the relationshipbetweenthe expression of BCRP and MDR1geneinpatients with Non-Hodgkin lymphoma. Methods The expression of BCRP and MDR1 gene in 66 NHL cases were examed by reverse transcriptase polymerase chain reaction(RT-PCR). Results The positive ratio of BCRP gene was 45.5% and MDR1 gene was 59.1% in 66 NHL. The response of treatment were different among the group of BCRP+MDR1+,BCRP+ MDR1-,BCRP-MDR1+and BCRP-MDR1(- 0.05). Conclusion Maybe the poor response of therapy has a close relation with the high expression of BCRP and MDR1.

About this research paper

What this paper is about

Objective To investigate the relationshipbetweenthe expression of BCRP and MDR1geneinpatients with Non-Hodgkin lymphoma. Methods The expression of BCRP and MDR1 gene in 66 NHL cases were examed by reverse transcriptase polymerase chain reaction(RT-PCR). Results The positive ratio of BCRP gene was 45.5% and MDR1 gene was 59.1% in 66 NHL. The response of treatment were different among the group of BCRP+MDR1+,BCRP+ MDR1-,BCRP-MDR1+and BCRP-MDR1(- 0.05). Conclusion Maybe the poor response of therapy has a close relation with the high expression of BCRP and MDR1.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To investigate the relationshipbetweenthe expression of BCRP and MDR1geneinpatients with Non-Hodgkin lymphoma. Methods The expression of BCRP and MDR1 gene in 66 NHL cases were examed by reverse transcriptase polymerase chain reaction(RT-PCR). Results The positive ratio of BCRP gene was 45.5% and MDR1 gene was 59.1% in 66 NHL. The response of treatment were different among the group of BCRP+MDR1+,BCRP+ MDR1-,BCRP-MDR1+and BCRP-MDR1(- 0.05). Conclusion Maybe the poor response of therapy has a close relation with the high expression of BCRP and MDR1.

Key concepts: Abcg2, Lymphoma, Cancer research, Medicine, Gene, Reverse transcriptase, Gene expression, Cancer

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
The gene expression and its clinical significance of breast cancer resistance protein (BCRP) and MDR1 in patients with non-hodgkin lymphoma — Research Paper | ScholarLens