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2010•Journal of Clinical HematologyRequires access

The expression of breast cancer resistance protein in patients with non-Hodgkin lymphoma

Xia Zhaoxiong

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Abstract

Objective:To investigate the expression of breast cancer resistance protein (BCRP ) gene and drug resistance in patients with non-Hodgkin lymphoma.Method:The expression of BCRP and MDR1 gene in 66 NHL cases were examed by reverse transcriptase polymerase chain reaction (RT-PCR). All patients were followed-up.Result:The positive ratio of BCRP gene was 45.5% and MDR1 gene was 59.1% in 66 NHL respectively. There was different positive ratio of BCRP gene in different pathologic types and clinical stages. The remission rate,recurrence rate and 5 years survival rate were all related with the expression of BCRP;The response of treatment were different among the group of BCRP+MDR1+,BCRP+ MDR1-,BCRP-MDR1+,and BCRP-MDR1-(P0.05).Conclusion:The poor response of therapy has close relation with the high expression of BCRP and MDR1.

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Objective:To investigate the expression of breast cancer resistance protein (BCRP ) gene and drug resistance in patients with non-Hodgkin lymphoma.Method:The expression of BCRP and MDR1 gene in 66 NHL cases were examed by reverse transcriptase polymerase chain reaction (RT-PCR). All patients were followed-up.Result:The positive ratio of BCRP gene was 45.5% and MDR1 gene was 59.1% in 66 NHL respectively. There was different positive ratio of BCRP gene in different pathologic types and clinical stages. The remission rate,recurrence rate and 5 years survival rate were all related with the expression of BCRP;The response of treatment were different among the group of BCRP+MDR1+,BCRP+ MDR1-,BCRP-MDR1+,and BCRP-MDR1-(P0.05).Conclusion:The poor response of therapy has close relation with the high expression of BCRP and MDR1.

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Available abstract

Objective:To investigate the expression of breast cancer resistance protein (BCRP ) gene and drug resistance in patients with non-Hodgkin lymphoma.Method:The expression of BCRP and MDR1 gene in 66 NHL cases were examed by reverse transcriptase polymerase chain reaction (RT-PCR). All patients were followed-up.Result:The positive ratio of BCRP gene was 45.5% and MDR1 gene was 59.1% in 66 NHL respectively. There was different positive ratio of BCRP gene in different pathologic types and clinical stages. The remission rate,recurrence rate and 5 years survival rate were all related with the expression of BCRP;The response of treatment were different among the group of BCRP+MDR1+,BCRP+ MDR1-,BCRP-MDR1+,and BCRP-MDR1-(P0.05).Conclusion:The poor response of therapy has close relation with the high expression of BCRP and MDR1.

Key concepts: Abcg2, Lymphoma, Medicine, Cancer research, Drug resistance, Breast cancer, Reverse transcriptase, Gene

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